Police say Robert Street East between Brock and Harriet streets in Penetanguishene is closed while emergency crews battle a fire.
According to the Southern Georgian Bay OPP, a house is fully engulfed in flames.
Police say Penetanguishene Fire, paramedic services and public utilities are on scene and are asking residents to stay clear of the area.
According to police, homes and businesses in the area may experience power outages as fire and emergency services manage the fire.
Police say more information will be released as it becomes available.