Police said a vehicle was driving in the westbound lane between Albert Street and Wascana Parkway at the time of the collision.
Officers were called to the incident shortly after midnight.
Police say the occupants of the vehicle were all male.
The driver, 23, was pronounced dead at the scene. A 22-year-old passenger was said to be in critical condition and the second passenger, 24, is in serious condition, police say.
The deceased’s’ next-of-kin has been notified. The investigation is ongoing, according to police.
Anyone with information is asked to contact police at 306-777-6500 of Crime Stoppers at 1-800-222-8477.