Two people were taken to hospital in critical condition and four others in serious condition after a serious crash on the Coquihalla Highway involving a semi-trailer.
Transportation officials closed the Highway in both directions between Hope and Merritt on late Friday morning, but reopened it to traffic in both directions by 5:30 p.m.
Motorists were warned to expect continued delays due to congestion.
BC Emergency Health Services said it was called to a crash involving three vehicles, including a semi-trailer, shortly before 11 a.m.
Two people were airlifted to hospital in critical condition, while four others were transported by ground ambulance.
The crash was reported between exits 256 and 202 on the highway. Travellers on social media reported the collision as just north of Larson Hill, about 35 kilometres south of Merritt.
Images captured by traffic cameras showed significant snow accumulation at higher elevations on the highway.