Const. Akhil Mooken told reporters that officers and paramedics were called to Bloor Street at Tomken Road before 12:15 a.m. with reports of a collision.
Mooken said the woman, who was a passenger in the SUV, was rushed to hospital by paramedics with life-threatening injuries. He said the male driver of the SUV died at the scene.
Also, an unconfirmed number of people on the bus at the time of the collision received minor injuries.
‘That ’90s Show’ trailer: Watch Red and Kitty Forman reopen their basement
‘Harry & Meghan’ trailer: Netflix shares 1st look at dramatic documentary
Major collision bureau and forensic identification investigators are looking into the circumstances leading up to the crash.
Anyone with information is asked to call police at 905-453-3311 or Crime Stoppers anonymously at 1-800-222-8477.