Westbound lanes of Highway 401 remain closed at Orford Road, near Ridgetown following a collision involving three tractor-trailers and another vehicle.
Chatham-Kent OPP say they were called to the scene shorty after 3 p.m. on Wednesday.
Police say traffic was stopped in the construction zone, but a westbound tractor-trailer failed to stop and collided into the rear of a stopped tractor-trailer.
According to police, the collision set off a chain reaction, as the first collision caused the tractor-trailer to collide with a third tractor-trailer, which then caused the third tractor-trailer to collide into the rear of a motor vehicle.
Police say the first and second tractor-trailers caught on fire and suffered extensive damage. One of the drivers of the tractor-trailers suffered minor injuries and was transported to hospital.
Police say charges are pending against a tractor-trailer driver, while the westbound 401 will remain closed at Orford Road for the next four hours as cleanup continues.