The right westbound lane of Highway 401 is open at Highway 6 South, near Guelph following a crash involving a car and tractor trailer early Wednesday morning.
Emergency crews were called to the scene just after 5 a.m.
OPP Sgt. Kerry Schmidt said one person was taken to hospital with life-threatening injuries.
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Schmidt said a fire completely destroyed the tractor trailer.
There is no word as to the cause of the incident.
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The remaining two left lanes will be closed for paving.
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