One person was killed in a two-vehicle collision on the Trans-Canada Highway near Sicamous on Saturday evening, the RCMP said.
Police were called to the site near Old Spallumcheen Road around 7:40 p.m.
Mounties said it appears an eastbound pickup truck crossed into the path of another westbound pickup truck.
The driver of the eastbound truck, a 52-year-old Alberta man, was taken to hospital with serious but non-life-threatening injuries.
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The driver of the westbound truck, a 48-year-old Kamloops man, died at the scene.
The crash closed the highway in both directions for hours overnight, but the road has since reopened.
Anyone with information or dashcam video is asked to contact B.C. Highway Patrol Revelstoke at 250-805-2111.