The Saskatoon police service along with fire crews, paramedics and water rescue were called to the area just north of the CP Train Bridge on Saturday morning for a person-in-distress.
At 11:47 a.m., first responders responded to the call.
Crews found and pulled the unconscious body of a man from the river.
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Police say CPR was administered unsuccessfully. The man was pronounced dead a short time later.
The investigation is ongoing.
More information will be released when it becomes available.