According to police, several armed people tried to force their way into a home in the 400 block of Avenue R South just after 7:30 p.m. Monday.
Occupants of the home became involved in a physical confrontation with one of the suspects, according to police.
The 14-year-old boy suffered serious, life-threatening injuries in the altercation, police said.
He was rushed to hospital where he was pronounced dead. His name was not released by police.
An autopsy was conducted Tuesday but police are not releasing a cause of death at this time.
The investigation continues and police are asking anyone with information to contact them at 306-975-8300 or Crime Stoppers at 1-800-222-8477.