The 50-year-old woman who was on remand was declared dead at the Prince Albert jail at around 7:30 p.m. after she was found unresponsive in her cell, says the ministry.
No foul play is suspected at this time, and the death is not related to COVID-19, say officials.
The woman’s next-of-kin have been notified.
The Prince Albert Police Service and the coroners service are also conducting its own investigations.
This is the third death of a Pine Grove inmate within nine months.
On July 1, a female inmate was transferred to a hospital in Saskatoon, where she was declared dead.
Weeks later, on July 29, a female inmate was pronounced dead after she was found unresponsive in her cell.
There have also been three inmate deaths this year at the Regina Correctional Centre.