A Winter Storm Warning has been issued for most of southern Ontario, including Hamilton, Burlington, Oakville and Niagara.
Global News chief meteorologist Anthony Farnell says we can expect to see periods of snow and blowing snow starting Saturday.
Farnell says apart from the brutal cold, 15 to 25 cm of snow is expected to be on the ground by Sunday afternoon.
Northeast winds will lend “a lake enhancement component to the storm,” he added, boosting local amounts up to 30 cm along sections of the QEW from Hamilton to Niagara.
Environment Canada says strong winds of 40 km/h, gusting to 60 km/h, will generate widespread blowing snow and bitterly cold wind chill values near – 20.
It says rapidly accumulating snow could make travel difficult over some locations.
WATCH: Global News meteorologist Jordan Witzel on what we can expect for the rest of winter
The weather agency says motorists should consider postponing non-essential travel until conditions improve.
Surfaces such as highways, roads, walkways and parking lots may become difficult to navigate due to accumulating snow.
For the latest forecast, please click here.