A physical fight was reported in the 3000-block of Arlington Avenue at roughly 7 p.m. CT.
Upon arrival, officers found the man suffering from multiple stab wounds. He was taken to Royal University Hospital in serious condition.
Members from targeted enforcement and forensic identification units are investigating.
Anyone with any information is asked to contact the Saskatoon police at 306-975-8300 or Crime Stoppers at 1-800-222-8477.