December 14, 2016 10:00 am
Updated: December 14, 2016 12:00 pm

Fertility, pregnancy and chronic illness: what you need to know

One in 10 women with at least one chronic disease gave birth to a premature infant, according to McMaster University researchers.

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This is the latest article in a Global News investigation into fertility in Canada, and the emotional and financial impact infertility has on Canadians struggling to conceive.

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Conceiving can be difficult and complicated for some healthy women – add a chronic illness to the mix and the chances of getting pregnant may become smaller.

According to McMaster University, about one in five pregnant women suffer from at least one chronic disease and are more likely to have their pregnancies (if they can get pregnant) deemed high-risk by their physicians. These researchers also admit their stats may not capture every complicated fertility case out there.

What’s more, Public Health Agency of Canada has found the rates of chronic illness in women (and men) are increasing rapidly – at about 14 per cent each year. As it stands now, three out of five Canadians older than 20 years of age have a chronic disease.

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So when it comes to chronically ill women wanting to conceive now – and in the future – hospitals around the world have had to adopt new practices and partnerships to help them through their pregnancies and possible fertility issues.

Dr. Darine El-Chaar is a maternal fetal medicine specialist at the department of obstetrics and gynecology at The Ottawa Hospital. One of her areas of expertise is helping women with chronic diseases navigate the process of having children.

According to El-Chaar, she treats more women in this scenario than many people may think.

“I’m a high-risk pregnancy physician and we do see a lot of these women,” she says. “We work with our partners in fertility and we often see the patients before they get pregnant. We do pre-conception counselling where we look at their medications, current condition and the progression of their disease.”

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During these meetings, El-Chaar says she is able to give women a sense of what they can expect with their pregnancy based on previous studies and other’s experiences.

Some of the common types of chronic illnesses she sees are lupus, diabetes and rheumatoid arthritis, among others.

But just because a woman is living with an illness, it doesn’t always mean she’ll experience infertility, a difficult pregnancy or be deemed high risk, says El-Chaar. In fact, for some, pregnancy could be a blessing in disguise.

Keeping a watchful eye

(It’s important to note that every patient’s situation is unique and patients should consult their physician for individual medical advice.)

Women living with chronic illness will often have their pregnancies deemed high risk. Sometimes that may mean physicians will take additional precautions when monitoring the pregnancy so both mom and baby come out healthy.

“Some conditions could mean that there is risk in the pregnancy,” says El-Chaar. “So we’ll do more ultrasounds – most women will only have two ultrasounds in their pregnancy – watch the fetus more carefully and watch [mom and baby] for complications we could expect related to blood pressure. So they’re in a much more controlled setting.”

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Some of those conditions in which El-Chaar keeps a close eye on include lupus, diabetes, and certain kidney and cardiovascular diseases (among others).

Women with cystic fibrosis are also watched closely.

“We’re seeing a lot more women with cystic fibrosis,” El-Chaar says. “They have blocked tubes so that’s what’s causing their lungs to be more of an issue so they have a lot of fertility issues. In these cases, a lot of these women need IVF because the tubes are closed so they can’t really conceive but it’s not completely impossible for them to get pregnant on their own.”

In terms of cancer, doctors will take the type of cancer the patient has (estrogen based versus non-estrogen based) into consideration.

According to El-Chaar, estrogen based cancers are sometimes discovered during pregnancy (like breast cancer). When this happens, El-Chaar says physicians will have a thorough discussion with the patient and come up with a detailed plan of action.

Depending on where the woman is at with her pregnancy, they may choose not to go through with the pregnancy and instead focus on treating the disease.

But there are other options, El-Chaar says.

Doctors have been able to determine that chemotherapy can still be given as a treatment during pregnancy – the trick is timing and the type of chemo agent being used.

“Sometimes the chemotherapy agents a patient has received could affect their cardiac action for example,” El-Chaar says. “I’ll watch them a little closer and do more imaging and testing of their heart.”

Pregnant patients can be given certain types of chemo after 12 weeks and be treated up to a certain point – sometimes up to 30 weeks El-Chaar says. This may cause babies to be born prematurely but otherwise healthy.

According to BabyCenter, other conditions that cause weight loss – like thyroid disorders – may interfere with ovulation and affect fertility, as well as chronic liver disease as it impedes with the functioning of the pituitary gland.

The upside

With certain diseases – like multiple sclerosis (MS), rheumatoid arthritis and psoriasis for example – fertility is not often impacted and pregnancy can actually help relieve some symptoms associated with the disease.

“Arthritis [for example] tends to get better during pregnancy,” says El-Chaar. “During pregnancy your body is less immunosuppressive because it’s making sure not to reject the fetus.”

Very similar to arthritis is psoriasis, says El-Chaar. (While many women report an improvement in their psoriasis, some experience a worsening, the National Psoriasis Foundation says.)

For patients with MS, many often experience fewer relapses in the disease over the nine months of pregnancy, according to the National Multiple Sclerosis Society.

(MS is a disease that affects the central nervous system, including the brain and spinal cord. It attacks myelin – the protective coating around the nerves – which causes inflammation and damages the myelin and nerve fibres, according to the MS Society of Canada.)

This clearing of symptoms, El-Chaar says, may be due to the role hormones (like progesterone and estrogen) play in the disease.

“[We think] the sex hormones probably help MS and decrease the symptoms,” El-Chaar says. “That’s why women with MS tend to fair better than men with MS. There’s something that happens in the blood-brain barrier where it decreases the disease’s progression.”

But because some of the medication MS patients take may be harmful to the fetus, women are often advised to stop taking them at least one full cycle prior to conceiving.

Unfortunately, there is a downside to this upside for women with these types of chronic illnesses, El-Chaar says.

“These women tend to have very strong postpartum flare ups,” she says. “I’ll still see [the patients after they deliver] and watch them closely just to monitor those flares.”

What you need to know

Thanks to medical advancements over the years, women with chronic illnesses are rarely advised against conceiving, McMaster University researchers say.

However, there is a higher potential for women with certain types of diseases to experience miscarriages.

“There’s something called antiphospholipid syndrome that comes with lupus – so for that subtype [there is higher risk],” says El-Chaar. “Another type is people with kidney failure just because their bodies are so unwell  sometimes they can have more miscarriages.”

(According to Mayo Clinic, antiphsopholipid syndrome happens when the immune system mistakenly attacks normal protein in the blood. This can cause blood clots within the arteries or veins and can cause pregnancy complications like miscarriages and stillbirths.)

El-Chaar also says some types of cardiovascular diseases may experience more miscarriages due to the added stress inflicted upon the heart.

Despite chronic illness, El-Chaar wants women to know that a healthy conception, pregnancy and delivery is possible with the proper medical support.

“Know your disease and be as healthy and stable as you can,” El-Chaar says. “The more optimized you are in your disease, the better the pregnancy and fetal outcome.”

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Graphics by Neil Sangani

© 2016 Global News, a division of Corus Entertainment Inc.

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