A 27-year-old woman has now been charged with second-degree muder in the killing of a 34-year-old man in the Joyce-Collingwood neighbourhood on Thursday.
Police were called to a home near Kingsway and Melbourne Street shortly after midnight.
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The victim was found with stab wounds and died before he could be taken to hospital.
Police have identified the victim as Brian Mathew Clayton.
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Dolly Patricia Capoose, 27, has been charged and remains in custody.
Investigators believe the suspect and victim knew one another.
Anyone with information is asked to contact Vancouver police at 604-717-2500.
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