A year after provincial governments clamped down on the most notorious name in prescription-drug abuse, other, more powerful, less regulated opioids are filling the void – with sometimes fatal results. More Canadians are popping pills than ever. And more of them are dying from it.

Health Canada doesn't think requiring potent painkillers to be tamper-resistant will have a significant effect on their misuse and abuse in Canada.

A study found half of the patients being started on fentanyl in Manitoba are being prescribed the drug unsafely.

Patients put on high doses of opioids are 24 times more likely to die because of them than people prescribed lower doses of the drugs, a new study finds.

Readers share their stories of struggling with opioid use, abuse and addiction.

The "data's mixed" on supervised injection sites, Stephen Harper says. What does the evidence say works -- and doesn't work -- when it comes to battling drug abuse and addiction?

Prescription opioids kill hundreds of Canadians a year. Why are doctors still prescribing so many?

Ontario needs to rethink the way it treats addiction and pain if it wants to tackle a worsening prescription opioid health crisis, critics say.

Preliminary 2013 data from Ontario's coroner indicates these powerful drugs are killing more people each year - and the usual suspects are being replaced by drugs that are just as addictive and even more potent.

In a call for proposals published Friday, the federal government said it’s looking for suggestions on how to make prescribing safer, including better training and education for the health professionals giving out these powerful painkillers.