According to West Kelowna Fire Rescue (WKFR), the fire occurred along the 1800 block of Old Boucherie Road at approximately 10 p.m.
When WKFR was first alerted to the fire, the report said there were possible occupants inside. However, when crews arrived, the occupants had evacuated the residence.
The two were sent to Kelowna General Hospital for treatment while WKFR doused the blaze.
Four fire engines and 18 firefighters were on scene.
WKFR says the fire’s cause was undetermined, but that investigators will continue their investigation on Saturday morning.