Emergency crews responded just before 8:30 p.m. Saturday to the intersection of Perth Road 164 (Highway 23) and Line 32.
It was determined a car going westbound on Line 32 and a snowplow going northbound on Perth Road 164 collided at the intersection, which is controlled by a stop sign in the east and west directions.
Police say the driver of the car was taken to hospital where they were pronounced dead.
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The deceased has been identified as 19-year-old Kylie McBeth of Moorefield.
A passenger in the car was also taken to hospital with minor injuries.
The driver of the snowplow was not injured.
Perth Road 164 between Frank Street and Perth Line 29, and Line 32 between Road 168 and Road 160 were closed for several hours but have since reopened.
Anyone with further information is asked to call the OPP at 1-888-310-1122 or Crime Stoppers at 1-800-222-8477 (TIPS).