Police say they responded Friday afternoon around 1 p.m. to reports of a collision on Westchester Bourne near Thompson Drive in the Municipality of Thames Centre.
Officials learned that a vehicle had left the roadway and struck a tree.
The driver was treated at the scene and taken to hospital where they later died of their injuries.
Police have identified the deceased as 56-year-old Aaron Fallowfield of London, Ont.
Anyone with further information is asked to contact OPP at 1-888-310-1122 or Crime Stoppers at 1-800-222-8477 (TIPS).