Moose Jaw RCMP responded to the crash shortly before noon. Early investigation indicates a southbound truck was attempting to avoid an SUV in front of it which was slowing down to make a turn.
In its attempt to avoid a fender bender, the truck veered into oncoming traffic and collided with a northbound car, carrying the two women injured.
Of the two injured, one woman was taken to a Regina hospital via STARS Air Ambulance.
RCMP say it believes alcohol was not a factor in the crash. The investigation is ongoing.