The Winnipeg Fire Paramedic Service responded to reports of a house fire on Saturday just after 6 a.m.
When crews arrived at the 300 block of Alfred Avenue they found heavy flames and smoke coming from the home.
Crews used aerial ladders to launch a defensive attack and to protect neighbouring homes from the spread of flames.
Nearby homes were temporarily evacuated as a precaution and no injuries were reported.
The cause of the fire is under investigation and no damage estimates are available, but the home is expected to be a total loss, officials said.