Police say the suspects allegedly forced their way into a home in the 1300 block of Robinson Street shortly before 6 a.m.
The suspects told the residents they were looking for two women, providing their names, according to police.
Police say one suspect reportedly assaulted a person inside the home and pointed a gun at another person.
EMS was not required in the incident, according to police.
Police describe one of the suspects as wearing a bandana over his face. No description was given for the second suspect.
Anyone with information is asked to contact Regina police at 306-777-6500 or Crime Stoppers at 1-800-222-8477.