The cocaine trafficking investigation in the city initially led to the arrest of a 24-year-old man on May 4.
A hotel suite was later searched in the 600-block of 25th Street East, where a 26-year-old man was also taken into custody.
Roughly 312 grams of packaged cocaine and over $38,000 in cash were seized, CFSEU said.
Items consistent with packing and processing cocaine — as well as a box of Arm & Hammer baking soda — were featured in a photo police provided of the seized items.
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The two Edmonton men have been charged with cocaine trafficking offences and possession of proceeds of crime over $5,000.
CFSEU is an investigative body, including members of Saskatoon police, with a mandate to disrupt and dismantle organized crime enterprises.