Emergency crews pulled a man out of a burning truck after it burst into flames following a crash on Circle Drive at Preston Avenue South.
Police said just before 3 a.m. Sunday, the westbound pickup truck went up the embankment at the Preston turnoff, went through the barricades and then over the four lanes on Preston before stopping west of the overpass.
The vehicle then burst into flames with the driver trapped inside.
The first officers on scene pulled the driver out of the pickup. He was taken to hospital with undisclosed injuries.
Saskatoon police said the truck had collided with several vehicles before leaving Circle Drive.
Traffic on Circle and Preston was restricted for around 10 hours while police carried out their investigation.