Firefighters said they could see flames and smoke coming from the second floor of the home.
Three people were evacuated from the building on fire while six others were evacuated from the two homes on either side.
Calgary Fire said there were no injuries but the home where the fire started will have to be torn down.
“I could see it from our backyard, but it’s a facade right now,” neighbour Samantha Keown said.
“You see the front (of the house) and the front looks fine, except the roof. (But) from the back it’s a husk. There’s nothing. It’s like an old western thing where it’s just the front frame and nothing back there.”
The two other homes suffered minor damage.
The fire took about one and a half hours to put out and the cause of the fire is still under investigation.
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