Drivers were being asked to avoid Highway 21 near Range Road 220 north of Hay Lakes, Alta., on Monday afternoon after a fiery crash involving two semi trucks.
RCMP said a semi truck hit another semi truck that had slowed down.
Both trucks caught fire, RCMP said.
One driver was taken to hospital with serious injuries, police added.
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Drivers were being asked to find alternate routes since the highway is expected to be closed until about 6 p.m. when the RCMP collision analyst completes their investigation.
Officers from Wetaskiwin and Camrose responded to the crash.