Drivers were being asked to avoid Highway 21 near Range Road 220 north of Hay Lakes, Alta., on Monday afternoon after a fiery crash involving two semi trucks.
RCMP said a semi truck hit another semi truck that had slowed down.
Both trucks caught fire, RCMP said.
One driver was taken to hospital with serious injuries, police added.
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Drivers were being asked to find alternate routes since the highway is expected to be closed until about 6 p.m. when the RCMP collision analyst completes their investigation.
Officers from Wetaskiwin and Camrose responded to the crash.
![Click to play video: '2 killed in 3-vehicle crash involving a semi on Highway 21 east of Edmonton'](https://i2.wp.com/media.globalnews.ca/videostatic/news/u35ihosa17-99qdzjnukg/Highway-21-pic.jpg?w=1040&quality=70&strip=all)
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