According to police, the collision happened on the Channel Parkway during the noon hour, and involved a motorcycle and a car turning left at an intersection.
Penticton RCMP say the Yamaha motorcycle was heading southbound, and collided with the northbound Volkswagen that was turning onto Green Mountain Road.
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Police say the motorcyclist, a 64 year-old man from Penticton, died at the scene. The driver of the Volkswagen, a 40 year-old man also from Penticton, was uninjured.
They added that there was no indication of criminality in the collision.