Police say around 1:50 p.m., a crash involving a car and a pickup truck happened at the intersection of Oxford Road 13 and Norwich Road.
Two adults and an 18-month-old baby were taken to hospital. One of the adults was later airlifted to a London-area hospital for further treatment.
OPP have arrested and charged the driver of the pickup truck, who reportedly fled westbound on Norwich Road after the collision.
A 41-year-old resident of Stoney Creek has been charged with dangerous driving and failing to stop at the scene of an accident.
The intersection at Oxford Road 13 and Norwich Road was closed for several hours but has since reopened.
The investigation is ongoing.
Police are asking anyone that may have dashcam or video surveillance footage to contact OPP investigators at 1-888-310-1122 or Crime Stoppers at 1-800-222-8477 (TIPS).