The Delta COVID-19 variant has a mutation called K417N. Here’s what we know

Click to play video: 'What scientists know about new ‘Delta Plus’ variant of concern'
What scientists know about new ‘Delta Plus’ variant of concern
WATCH: Scientists have identified another COVID-19 variant of concern, called Delta Plus. So how dangerous or contagious is this mutation? – Jun 23, 2021

India said on Wednesday it has found around 40 cases of the Delta coronavirus variant carrying a mutation that appears to make it more transmissible and advised states to increase testing.

Below is what we know about the variant.

What is Delta plus?

Click to play video: '‘Delta Plus:’ India state health minister orders close monitoring of COVID-19 variant mutation'
‘Delta Plus:’ India state health minister orders close monitoring of COVID-19 variant mutation

The variant, called “Delta Plus” in India, was first reported in a Public Health England bulletin on June 11.

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It is a sub-lineage of the Delta variant first detected in India and has acquired the spike protein mutation called K417N which is also found in the Beta variant first identified in South Africa.

Some scientists worry that the mutation, coupled with other existing features of the Delta variant, could make it more transmissible.

READ MORE: ‘Delta plus’ — India declares new COVID-19 variant to be of concern

“The mutation K417N has been of interest as it is present in the Beta variant (B.1.351 lineage), which was reported to have immune evasion property,” India’s health ministry said in a statement.

Shahid Jameel, a top Indian virologist, said the K417N was known to reduce the effectiveness of a cocktail of therapeutic monoclonal antibodies.

Where has it been found?


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As of June 16, at least 197 cases has been found from 11 countries – Britain (36), Canada (one), India (eight), Japan (15), Nepal (three), Poland (9), Portugal (22), Russia (one), Switzerland (18), Turkey (one), the United States (83).

India said on Wednesday around 40 cases of the variant have been observed in the states of Maharashtra, Kerala and Madhya Pradesh, with “no significant increase in prevalence.” The earliest case in India is from a sample taken on April 5.

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U.K. researchers say Delta variant presents new pattern of symptoms

Britain said its first five cases were sequenced on April 26 and they were contacts of individuals who had travelled from, or transited through, Nepal and Turkey.

No deaths were reported among the U.K. and Indian cases.

What are the worries?


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Studies are ongoing in India and globally to test the effectiveness of vaccines against this mutation.

“WHO is tracking this variant as part of the Delta variant, as we are doing for other Variants of Concern with additional mutations,” the World Health Organization (WHO) said in a statement sent to Reuters.

“For the moment, this variant does not seem to be common, currently accounting for only a small fraction of the Delta sequences. … Delta and other circulating Variants of Concern remain a higher public health risk as they have demonstrated increases in transmission,” it said.

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Delta COVID-19 variant, low vaccination rates raise concerns of resurgence in U.S.

But India’s health ministry warned that regions where it has been found “may need to enhance their public health response by focusing on surveillance, enhanced testing, quick contact-tracing and priority vaccination.”

There are worries Delta Plus would inflict another wave of infections on India after it emerged from the world’s worst surge in cases only recently.

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“The mutation itself may not lead to a third wave in India — that also depends on COVID-appropriate behaviour, but it could be one of the reasons,” said Tarun Bhatnagar, a scientist with the state-run Indian Council for Medical Research.

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