RCMP said they responded to 24 calls in regards to motor vehicle collisions and 15 calls where vehicles were stuck on the road or in the ditch, as of 9 a.m. Tuesday.
Roads in the southeast portion of Saskatchewan are extremely slippery, RCMP said, with many highways still closed.
RCMP responded to about a dozen collisions on Highway 1 east of Regina. Parts of Highway 1 remain closed.
At about 7:15 a.m. Tuesday, White Butte RCMP responded to a jack-knifed semi across both westbound lanes of Highway 1 two miles west of the Grand Coulee exit.
Motorists were re-routed on grid roads and the roadway was cleared at about 12 p.m. Tuesday.
No injuries were reported.
At about 3 p.m. Tuesday, Indian Head RCMP said it is on scene for several collisions on Highway 1 east of Regina with no injuries reported.
Three miles of east Wolseley, the eastbound lane on Highway 1 is completely blocked off due to a jack-knifed semi. Again, no injuries are being reported.
The jack-knifed semi has caused traffic to be backed up and RCMP said it cannot re-route traffic at this time.
Traffic can expect delays for at least the next three to four hours.
People are being asked to avoid travelling in this region and to check the provincial highway hotline to see which roads are open and closed.
RCMP are also asking people to plan for interruptions, delays or emergencies.
Carlyle, Oxbow, Carnduff, Bienfait, Stoughton, Moosomin, Grenfall, Kipling, Wawota, are currently under a snowfall warning, according to Environment Canada.
Assiniboia, Gravelbourg, Coronach, Regina, Estevan, Weyburn, Radville, Milestone, Fort Qu’Appelle, Indian Head, Lumsden, Pilot Butte, Moose Jaw, Pense, Central Butte and Craik were under a blowing snow advisory, but not anymore.
“Visibility may be suddenly reduced at times in heavy snow. Surfaces such as highways, roads, walkways and parking lots may become difficult to navigate due to accumulating snow,” Environment Canada posted on its website.
In Regina, police reported nine collisions involving property and vehicles over the past 24 hours.
From 9 p.m. Monday to 12 p.m. Tuesday police reported five property damage collisions. In the past 24 hours, no collisions resulted in injuries.