Icy roads may be factors in at least 16 crashes in and around Saskatoon on Friday morning, police said.
The most serious crash reported so far happened just outside of Saskatoon.
Two people were injured, one seriously, RCMP said.
The highway is closed and traffic is currently being detoured.
Saskatoon police have responded to a least 15 crashes in the city.
One happened on Circle Drive near 33rd Street during the morning commute and involved multiple vehicles.
Another happened on Circle Drive near Taylor Drive when a vehicle rolled over in the northbound lanes, police said.
No injuries were reported in any of the collisions in Saskatoon, police said.
Police said they are reminding drivers to slow down and give themselves more time to reach their destination.
City officials said crews were out overnight applying salt to prevent icing on high-traffic priority streets, and 16 sanders continue to apply salt on roads.
For drivers heading out on provincial highways, the latest road conditions can be found online at the Highway Hotline website.