By the end of the first quarter, Saskatoon led Edmonton 14-0 with touchdowns by Ben Abrook and Tanner Rhode.
Connor Graham, Keegan Dicks and Dillan Heintz also helped the Toppers’ gain a commanding 35-0 lead with first-half touchdowns.
Running back Carter McLean got the Hilltops’ lone touchdown of the third quarter.
Rylan Kleiter chipped in his second field goal of the second half and the Hilltops held on for the rest of the fourth quarter.
The Toppers captured their second-straight perfect regular season with the win, while also extending their winning streak to 27 games in the Canadian Junior Football League.
Saskatoon (8-0) and Edmonton (2-6) will meet again in the Prairie Football Conference semifinal on Oct. 20.