RCMP said they attended the scene at 4:42 p.m. after a southbound service truck and an SUV collided head-on in the southbound lane.
EMS arrived on scene and the passenger of the southbound vehicle, a 75-year-old woman, was pronounced dead at the scene. Her name has not been released.
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The 80-year-old driver of the SUV was taken to hospital with injuries. RCMP said the severity of his injuries are undetermined.
The driver of the truck was treated by EMS at the scene and released.
The collision is under investigation and RCMP Collision Reconstructionists were on scene with the coroner following the crash.
The highway was shut down until 11 p.m. Friday.
Osler is about 30 kilometres northeast of Saskatoon.
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