Wellington County OPP say the man killed in a crash near Arthur is 43-year-old Darren James More of Palmerston.
Emergency crews rushed to the intersection of Concession 16 and Sideroad 15 on Wednesday at around 8 a.m. after two pickup trucks collided.
More, the driver of one of the trucks, was rushed to hospital where he later died from his injuries.
Two passengers in the other pickup truck suffered serious injuries and were airlifted to hospital by ORNGE ambulance.
The driver of the other truck, a 21-year-old man from Listowel, was arrested and charged with driving under the influence of drugs causing death and two counts of driving under the influence of drugs causing bodily harm.
OPP said the truck he was driving may have been stolen.
Traffic in the area was diverted for several hours, but the roads have since reopened.
Anyone who witnessed the crash or may have information is asked to call Wellington County OPP.