Around 4:10 p.m., Airdrie RCMP was called to the scene of the crash on Highway 567 and Range Road 270.
RCMP said both vehicles were travelling west on Highway 567 when the school bus slowed down to make a left turn. While the motorcyclist attempted to pass, police said it collided with the front end of the bus.
The 62-year-old Cochrane man driving the motorcycle was killed instantly as a result of the crash.
Nobody on the bus was hurt, RCMP said. Two children were on board at the time.
An RCMP collision reconstructionist was called to the scene.
Highway 567 at Township Road 270 remained closed for investigation late into Tuesday night.
Drivers were asked to avoid the area until the road was cleared.
— With files from Jessika Guse, Global News