Wynyard and Foam Lake RCMP were called to the scene at about 3:45 p.m. on Friday.
Investigators learned the vehicle was travelling westbound when it left the highway and entered a nearby creek.
There were two people inside the vehicle, RCMP says. The driver was declared dead at the scene. The passenger received minor injuries.
The man’s family has been notified.
Traffic on Highway 16 was restricted during the preliminary investigation but has since reopened.
Wynyard RCMP and an RCMP traffic reconstructionist continue their investigation.