Advertisement

Pfizer says its coronavirus vaccine appears to work against U.K., South Africa variants

Click to play video 'Coronavirus: Canada ‘not expecting’ large numbers of cases related to COVID-19 variants, Tam says' Coronavirus: Canada ‘not expecting’ large numbers of cases related to COVID-19 variants, Tam says
Coronavirus: Canada ‘not expecting’ large numbers of cases related to COVID-19 variants, Tam says – Jan 5, 2021

Pfizer Inc and BioNTech’s COVID-19 vaccine appeared to work against a key mutation in the highly transmissible new variants of the coronavirus discovered in the UK and South Africa, according to a laboratory study conducted by the U.S. drugmaker.

The study by Pfizer and scientists from the University of Texas Medical Branch, which has not yet been peer-reviewed, indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.

Read more: What the COVID-19 variant from South Africa means for pandemic, vaccines

The mutation is linked to greater transmissibility and there had been concerns it could also make the virus escape antibody neutralization elicited by the vaccine, said Phil Dormitzer, one of Pfizer’s top viral vaccine scientists.

The first results of tests on the variants offer some hope as Britain and other countries try to tame the more infectious variants which authorities believe are driving a surge in infections that could overwhelm healthcare systems.

Story continues below advertisement

The study was conducted on blood taken from people who had been given the vaccine. Its findings are limited because it does not look at the full set of mutations found in either of the new variants of the rapidly spreading virus.

Click to play video 'Coronavirus: WHO says no evidence that new strain of virus in South Africa is more transmissible' Coronavirus: WHO says no evidence that new strain of virus in South Africa is more transmissible
Coronavirus: WHO says no evidence that new strain of virus in South Africa is more transmissible – Jan 5, 2021

Dormitzer said it was encouraging that the vaccine appears effective against the mutation, as well as 15 other mutations the company has previously tested against.

[ Sign up for our Health IQ newsletter for the latest coronavirus updates ]

“So we’ve now tested 16 different mutations, and none of them have really had any significant impact. That’s the good news,” he said. “That doesn’t mean that the 17th won’t.”

Dormitzer said another mutation found in the South African variant, called the E484K mutation, was also concerning.

Read more: BioNTech CEO says coronavirus vaccine ‘highly likely’ to protect against new strain

Story continues below advertisement

CONSTANT MONITORING

The U.S. researchers plan to run similar tests to see whether the vaccine protects against other mutations found in the British and South African variants and hope to have data within weeks.

The variants are said by scientists to be more transmissible than previously dominant ones, but they are not thought to cause more serious illness.

Independent experts gave a cautious welcome to the Pfizer study findings, but said the situation needs constant vigilance.

Paul Hunter, a professor in medicine at Britain’s University of East Anglia, said “the jury is still out on the impact of the South African variant on vaccine efficacy.”

Click to play video 'Coronavirus: ‘It is normal to expect variants’ of COVID-19 virus, says Operation Warp Speed chief adviser' Coronavirus: ‘It is normal to expect variants’ of COVID-19 virus, says Operation Warp Speed chief adviser
Coronavirus: ‘It is normal to expect variants’ of COVID-19 virus, says Operation Warp Speed chief adviser – Jan 3, 2021

Deborah Dunn-Walters, a professor of immunology at Surrey University in Britain, said it was “reassuring” that Pfizer is closely monitoring variants.

Story continues below advertisement

Ongoing testing will be needed, experts said, to allay concerns about whether vaccines being given to millions of people in the fight against the pandemic will protect them as the virus mutates. COVID-19 has killed more than 1.8 million people worldwide.

“The evidence is not conclusive but there is a lot to indicate that the existing MRNA vaccines do cover the new variants. That is the good news,” Andreas Bergthaler, principal investigator at the Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna.

Click to play video 'Canadian scientists work to track new coronavirus variant' Canadian scientists work to track new coronavirus variant
Canadian scientists work to track new coronavirus variant – Jan 1, 2021

TESTS AND TWEAKS

AstraZeneca, Moderna and CureVac are also testing whether their shots will protect against the fast-spreading coronavirus variants. They have said they expect them to be effective, but have not said when study results will be published.

A senior British lawmaker expressed concerns in an interview on Friday that COVID-19 vaccines might not work properly against the South African variant. He was not responding to questions about Friday’s data.

Story continues below advertisement

The Pfizer/BioNTech COVID-19 vaccine and the one from Moderna Inc, which use synthetic messenger RNA technology, can be quickly adapted to address new mutations in the coronavirus if necessary. Scientists have suggested the changes could be made in as little as six weeks.

The variant is not the first of the pandemic to emerge and Eleanor Riley, a professor of immunology and infectious disease at the Edinburgh University, said similar studies would need to be repeated as new mutations appear. “It may be necessary to tweak the vaccine over time,” she said.