Police were called to the 500 block of Broad Street at around 8:30 p.m. after receiving a report that a business was being robbed.
According to police, a male suspect entered the business armed with a handgun.
The suspect forced the employee at gunpoint to give up an undisclosed amount of cash, said Regina police in a press release.
The employee was not harmed, say police.
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Police describe the suspect as a male with a medium build and dark complexion. He is 20 to 25 years old and was wearing a black hoodie with the hood up, blue jeans, a medical mask, white shoes with three black stripes up the side, and clear gloves.
Anyone with information is asked to contact the Regina Police Service at 306-777-6500 or Crime Stoppers at 1-800-222-8477.