White, 62, hosted the game show by herself for the first time in the show’s history while Pat Sajak is on a temporary medical hiatus.
Sajak had to undergo emergency surgery for a blocked intestine.
Minnie Mouse took over White’s duties turning the letters, which she has been doing for more than 35 years.
Ahead of the show on Monday night, White tweeted that she was “excited and nervous.”
Wheel of Fortune shared a video of White spinning the wheel halfway around a full rotation for the final spin.
“That wheel is heavy!” she told the audience.
“Oh no! My first spin, look at that,” she said, thinking she had landed on “Bankrupt.”
The arrow actually landed on “$500” and White said: “Oh no, I’m looking at the wrong arrow! How do you do this show?”
The episodes were filmed in November while Sajak was recovering from surgery. He thanked his fans for their support in early November.
“Wheel of Fortune without @patsajak is like a word without vowels,” White tweeted. “I’ll fill in the blanks until you return. Rest up and we’ll be solving puzzles in no time. (Don’t worry, your job is safe! Well, pretty safe.)”
On Saturday, Sajak tweeted: “It’s a bit confusing, but here’s the deal: Vanna will be hosting this coming week and the next. Then two weeks of shows I taped before my surgery. Then Vanna again the week of Jan. 6 with a special guest at the puzzle board. Then the planets will realign, and it’s back to normal.”
White will also host another week of Wheel of Fortune in early January from the 6th through the 10th.
White filled in once for one segment of the show in 1996 when Sajak had laryngitis.