The seizure occurred in the 1400-block of Central Avenue at around 1:30 p.m. on Thursday.
Three men, aged 27, 29 and 30, were arrested.
Nearly 32 grams of methamphetamine, 15.7 grams of cocaine, a large machete, a can of bear spray, and over $7,000 in cash were found during a search of the vehicle, Prince Albert police said.
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All three men are facing charges of possession of drugs for the purposes of trafficking, possession of the proceeds of crime, and possession of a dangerous weapon in relation to this incident.
The accused made their first Prince Albert provincial court appearance on Friday morning, according to police.