The rollover blocked the westbound lanes of the south Perimeter at the Pembina Highway overpass.
RCMP said it happened just before 10 a.m. Thursday as the truck was merging onto the Perimeter from Pembina Highway.
Sgt. Paul Manaigre said the closure was expected to last several hours as the trailer has to be unloaded before it could be flipped upright.
The road was re-opened at about 2:45 p.m.
No injuries were reported.