City of Kawartha Lakes OPP are investigating a two-vehicle crash at Valentia and Ramsey roads on Wednesday around 2:15 p.m.
Police said a pickup truck heading south on Valentia hit an SUV going east on Ramsey Road.
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The male driver and lone occupant of the truck was airlifted from the scene and sent to a Toronto hospital with serious injuries.
Two people in the SUV were sent to a local hospital via ambulance with minor injuries.