Det. Sgt. Nunzio Tramontozzi said police have seen a surge in such cases over roughly the past two years.
He said human traffickers may opt to use Airbnb rentals instead of motels or similar venues because of the greater possibility for anonymity.
In the most recent case, he alleges two 18-year-old men forced a 19-year-old woman into the sex trade for more than a month, conducting most of their business at various Airbnb properties in the Greater Toronto Area.
The teens are now facing a total of 58 charges, and police say the woman is receiving medical help and support for her ordeal.
Tramontozzi says people thinking of listing their properties on Airbnb should be more diligent in checking on prospective renters, but did not offer specific guidance.
Airbnb said it worked with Toronto police on the latest case and noted that it takes the challenge of confronting human trafficking very seriously.