Wakaw RCMP say narcotics were stolen by three masked men from a pharmacy in Cudworth, Sask., on Wednesday.
The men broke into the business while wearing gloves at around 5 a.m. CT.
Police said they made off with an undisclosed amount of narcotics from a locked cabinet in the dispensary.
The men, along with a woman, fled in a grey four-door 2008 Pontiac Grand Prix with Saskatchewan licence plate 431 KGW.
RCMP are asking the public not to approach the vehicle or its occupants.
Anyone with information is asked to contact Prince Albert RCMP at 306-365-1370 or Crime Stoppers at 1-800-222-8477.
Cudworth is approximately 80 kilometres northeast of Saskatoon.