Emergency crews were called to the scene of a collision in the southbound lane of the North Perimeter Highway, just south of the Highway 6 intersection, around 6:25 a.m.
Police say a vehicle heading south lost control and slid across the median before crashing into a northbound pickup truck.
RCMP reported icy conditions on the highway around Winnipeg Thursday morning.
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In a release Friday police said the driver of the southbound vehicle, an 18-year-old woman from Winnipeg, was rushed hospital where she later died.
The driver of the pickup truck, a 67-year-old man from Portage la Prairie, was taken to hospital with non-life threatening injuries.
RCMP continue to investigate.