At 4:20 p.m., police received a report of a collision on Oxford Road 29 in Blandford-Blenheim Township.
According to police, the pedestrian was taken to hospital with serious, life-threatening injuries where they later died.
The victim has been identified as Bradley Determann, 26, of Erin, Ont.
The investigation into the collision is ongoing.
Anyone with information is asked to contact the Oxford OPP at 1-888-310-1122.