Police say they were called to the 500 block of Wascana Street at about 1:30 a.m. for a report of a man who was critically injured.
The man was alive when police got there and officers attempted emergency first aid while waiting for EMS to arrive, police say. He died a shortly after.
The Saskatchewan Coroner Service is working with police on the investigation.
Anyone with information is asked to contact police at 306-777-6500 or Crime Stoppers are 1-800-222-8477.