RCMP were called to a residential fire at about 10:30 a.m. on Victoria Avenue in Coronation, Alta., on Monday.
Police responded at about 11 a.m., along with the fire department.
A woman was found inside the home and taken to hospital where she was pronounced dead a short time later.
The Office of the Fire Commissioner and RCMP continue to investigate the incident.
RCMP said the cause was still undetermined Monday evening.
Coronation is located about 260 kilometres southeast of Edmonton and about 300 kilometres northeast of Calgary.