Drivers were being warned to expect major delays and congestion, after Highway 99 was temporarily closed at Porteau Cove Road due to a serious crash Tuesday evening.
Squamish RCMP said it happened at about 4:45 p.m., and involved two vehicles.
BC Emergency Health Services says two people were transported to hospital, one in serious condition, and one in stable condition.
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At least one person was initially trapped in a vehicle, police said.
DriveBC said it would provide an update on the closure at 7 p.m.