Officials say a water main break has caused the northbound lanes of Yonge Street between Queen and Dundas streets to be closed.
The City of Toronto also said westbound Shuter Street is closed from Yonge to Victoria streets.
The southbound lanes on Yonge Street in the area are open to traffic.
There is no word on the cause of the water main break.
Crews are on the scene trying to repair and clean up the large amount of water on the roadway.